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Ocular Diseases

There is a significant unmet need in the treatment of corneal endothelial disease Corneal endothelial disease is a serious and potentially debilitating condition, affecting millions of people throughout the world. What is corneal endothelial disease?

  • The corneal endothelium is a single layer of cells located on the posterior of the eye’s cornea. A healthy cornea is essential for vision
  • Typically, an adult cornea has a density of about 3,000 endothelial cells/mm8 in its central area
  • Corneal endothelial cells may degrade and are lost with age or as a result of diseases, such as:

Corneal endothelial cells do not naturally regenerate; when lost, they are gone forever.

As endothelial cell loss worsens:

  • The remaining cells can spread to cover the exposed portions of the cornea to maintain visual function
  • However, as corneal endothelial cells enlarge and as density decreases to 400 cells/mm2 or fewer, the remaining cells may be unable to keep the cornea dry and maintain functional vision
  • Corneal edema (swelling) may occur, with associated vision loss
  • In addition, epithelial edema may occur, which can result in a painful, debilitating foreign body sensation in the eye

While these surgical procedures have proven effective, they require healthy donor corneas in a 1:1 ratio (one healthy donor cornea to treat each diseased cornea). The global supply of donor corneas cannot address the need caused by corneal endothelial disease