Guttae Morphology After Cultured Corneal Endothelial Cell Transplant in Fuchs Endothelial Corneal Dystrophy

This prospective case series demonstrates that surgically scraping and polishing away guttae while preserving the Descemet membrane—followed by cultured corneal endothelial cell therapy—successfully reduces guttae formation in patients with Fuchs dystrophy. Crucially, the study found no increase or recurrence of these abnormal matrix deposits for up to three years post-surgery, offering a less invasive approach to managing the disease.